The transition metal-catalyzed synthesis of bicyclo[4.1.0]heptenes from 1,6-enynes has emerged as an efficient strategy for constructing strained carbo- and heterocycles. Recent advancements using gold, platinum, iridium, rhodium, and manganese catalysts have enhanced selectivity and functional group tolerance. This review explores recent developments and mechanistic insights in this field, emphasizing their potential for synthesizing biologically relevant molecules with diverse applications.

Abstract

Bicyclo[4.1.0]heptene derivatives are an essential class of strained carbo- and heterocycles that have garnered significant interest due to their diverse biological applications, such as antitumor, antibacterial, and antiviral activities, etc. Over the past decade, transition metal-catalyzed one-pot strategies have emerged as efficient and selective methods for synthesizing bicyclo[4.1.0]heptenes from 1,6-enynes. This review highlights recent advancements in this field, emphasizing catalytic transformations facilitated by gold, platinum, iridium, rhodium, and manganese complexes. Additionally, mechanistic insights and reaction scope of these methodologies are discussed, underscoring their efficiency, selectivity, and applicability in constructing complex molecular structures.