Synthesis of Multisubstituted Pyranoindol‐1‐ones Using Iridium‐Catalyzed Intramolecular C─H Amination of 3‐Amino‐4‐phenyl‐2‐pyrones
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A method for the synthesis of multisubstituted pyranoindol-1-ones is developed, utilizing iridium-catalyzed intramolecular C─H amination of 3-amino-4-phenyl-2-pyrones synthesized via the conjugate addition of diethyl 2-aminomalonate to alkynyl ketones. This synthetic strategy was successfully applied to the synthesis of analogues of biologically active compounds.
Abstract
A method for the synthesis of multisubstituted pyranoindol-1-ones is developed, utilizing iridium-catalyzed intramolecular C─H amination of 3-amino-4-phenyl-2-pyrones synthesized via the conjugate addition of diethyl 2-aminomalonate to alkynyl ketones. This synthetic strategy was successfully applied to the synthesis of analogues of biologically active compounds.
