Safe and Sustainable solvents are currently overlooked in semiconductor photocatalysis, undermining its core sustainability goals. This scientific perspective calls for academia–industry collaboration to advance solvent sustainability, proposing a workflow for rational solvent selection that balances performance and environmental impact, enabling long term sustainable practices in semiconductor photocatalysis.

Semiconductor photocatalysis has gained recognition for its sustainability and has seen considerable advancements in recent decades. Despite this progress, the critical role of solvents in influencing photocatalytic performance remains underexplored, particularly in the context of safe and sustainable solvent systems. This perspective advocates for a systematic shift toward the use of safe and sustainable solvents and proposes a rational workflow for their selection, moving beyond conventional trial-and-error methods. Key challenges in adopting this approach are discussed, along with future directions that call for coordinated efforts across academia and industry. Central to this vision are the development of a comprehensive solvent database, predictive models for solvent effects, and a standardized safety and sustainability ranking system that integrates both green chemistry metrics and life cycle assessments.