We disclose herein a Rh(III)-catalyzed weakly co-ordinating inherent functional group assisted dual C─H annulation of isoquinolones with 1,6-diynes, enabling the rapid construction of naptho-fused polycyclic derivatives.

Abstract

Transition metal-catalyzed annulations of unsaturated systems through dual C─H activation represent a straightforward tool to access multi cyclic scaffolds. We disclose herein, a Rh(III)-catalyzed weakly coordinating inherent functional group assisted dual C─H annulation of isoquinolones with 1,6-diynes. Some necessary control experiments were conducted to untangle the reaction mechanism.