The polaronic effects at the atomic level hold paramount significance for advancing the efficacy of transition metal oxides in applications pertinent to renewable energy. The lattice-distortion mediated localization of photoexcited carriers in the form of polarons plays a pivotal role in the photocatalysis. By employing Hubbard-U corrected and hybrid density functional theory (DFT) methods, we systematically probe the polaronic effects in the catalysis of oxygen evolution reaction (OER) on the (110) surface of rutile TiO2 photocatalyst. Theoretical understanding of polarons within the surface, coupled with simulations of OER at distinct titanium (Ti) and oxygen (O) active sites, reveals diverse polaron formation energies with strong preference for bulk and surface bridge oxygen sites. Moreover, we provide the evidence for the facilitative role of polarons in OER. We find that hole polarons situated at subsurface, equatorial, and bridge site significantly reduce the Ti-active site OER overpotential by ~0.4 eV through the peroxo-oxygen pathway. We also observe that the presence of hole polarons stabilizes the *OH, *O, and *OOH intermediate species. Overall, this study provides a detailed mechanistic insight into polaron-mediated OER, offering a promising avenue for improving the catalytic activity of transition metal oxide-based photocatalysts.