ARTIKEL
One‐Pot Gold/Acid‐Catalyzed Synthesis of Indolo[1,2‐a ]quinolin‐5(6H )‐ones from 1‐(2‐Ethynylphenyl)‐1H ‐indoles
![One‐Pot Gold/Acid‐Catalyzed Synthesis of Indolo[1,2‐a
]quinolin‐5(6H
)‐ones from 1‐(2‐Ethynylphenyl)‐1H
‐indoles](/_next/image?url=%2F_next%2Fstatic%2Fmedia%2Fplaceholder.d488439a.png&w=3840&q=75)
We present a method for the synthesis of substituted indolo[1,2-a]quinoline-5(6H)-ones starting from 1-(2-ethynylphenyl)-1H-indoles. The transformation involves gold-catalyzed oxidation of the triple bond followed by acid-promoted intramolecular cyclization at the indole C2 position. Demonstrating noteworthy versatility, the reaction tolerates a wide array of substituents on the indole core and proceeds in good to excellent yields (up to 93%).
![One‐Pot Gold/Acid‐Catalyzed Synthesis of Indolo[1,2‐a
]quinolin‐5(6H
)‐ones from 1‐(2‐Ethynylphenyl)‐1H
‐indoles](/_next/image?url=%2F_next%2Fstatic%2Fmedia%2Fplaceholder.d488439a.png&w=256&q=75)
![One‐Pot Gold/Acid‐Catalyzed Synthesis of Indolo[1,2‐a
]quinolin‐5(6H
)‐ones from 1‐(2‐Ethynylphenyl)‐1H
‐indoles](/_next/image?url=https%3A%2F%2Fcdn.gdch.de%2Fprod%2Flarge_Social_Media_innovationspreis_patentrecht_2027_b3d4ce56e4.png&w=256&q=75)
![One‐Pot Gold/Acid‐Catalyzed Synthesis of Indolo[1,2‐a
]quinolin‐5(6H
)‐ones from 1‐(2‐Ethynylphenyl)‐1H
‐indoles](/_next/image?url=https%3A%2F%2Fcdn.gdch.de%2Fprod%2FPrimo_Levi_02dcfff876.png&w=256&q=75)
![One‐Pot Gold/Acid‐Catalyzed Synthesis of Indolo[1,2‐a
]quinolin‐5(6H
)‐ones from 1‐(2‐Ethynylphenyl)‐1H
‐indoles](/_next/image?url=https%3A%2F%2Fcdn.gdch.de%2Fprod%2Flarge_Foto_Ullrich_Scherf_cfbbe88e88.jpg&w=256&q=75)
