Herein we highlight key concepts behind unconventional synthetic routes towards the synthesis of N-nitrosamines in comparison to traditional chemical routes. These include electrochemical, photochemical, and flow methodologies. Easier and cleaner access to N-nitrosamines is desirable for their use as intermediates and as analytical standards, due to their carcinogenic nature and low-tolerance thresholds in medicinal compounds.

Abstract

N-Nitrosamines acting as contaminants in our environment is a topic of increasing concern. Detection methods are required, necessitating analytical standards. Herein, we discuss some conventional methodologies to prepare N-nitrosamines and compare them with unconventional pathways towards their synthesis. These methods are often more environmentally benign and safer.