In their Research Article (e202508481), Lenard Saile and Kun Dai et al. describe a feedback mechanism that controls non-equilibrium systems. Enantiomeric aminoacyl phosphates, depicted as left and right hands drive the formation of distinct peptide assemblies. These structures, in turn, regulate the kinetics of the reaction cycle, providing control through stereochemical information rather than broad structural changes. The image was created by Ella Maru studio.