The Front Cover illustrates the catalytic dynamics of transition metal carbide catalysts during the hydrodeoxygenation (HDO) reaction and highlights that the transition metal oxycarbide species formed during the reaction play a key role in governing both HDO activity and selectivity. This study underscores the need to investigate the nature of active sites under operando conditions to establish rational structure-activity relationships. Further details can be found in the Research Article by G. Li and co-workers (DOI: 10.1002/cctc.202500659).