This image shows the crystal structure of the N-terminal domain of clathrin with the known binding sites colored. Site 1 is colored in yellow, and an expansion shows a stylized image of the predicted binding of a Pitstop 2 analogue compared to Pitstop 2 in binding site. The background shows a selection of the Pitstop 2 analogues described in the article in various colors. More details can be found in research article 10.1002/cmdc.202500321 by Adam McCluskey and co-workers.